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A comparative study of Salvia miltiorrhiza Radix & Rhizoma raw material and granule products using chromatographic analysis and antioxidant activity

Author: Zhou a, Valentina a, b, *, Mendoza a, John a, Kelvin

Doi: https://ctm.2023.v6.i6.pp01-15


One common medicinal preparation used in traditional Chinese medicine is granules of botanical extracts. But there is no assessment of their quality or effectiveness. Dan Shen (Salvia miltiorrhiza Radix & Rhizoma) granule extracts and their herbal counterparts were the subjects of this comparative investigation on antioxidant activity and purity. Methods: A comparison was made between the herb's water extracts and 12 granule extracts using a chromatographic technique to ascertain the concentration of seven marker chemicals. Principal component analysis (PCA) and agglomerative hierarchical clustering (AHC) were used to differentiate the herbal and granule extracts according to the marker chemical content. This study used DPPH, ferric ion reducing antioxidant power (FRAP), and 2, 20-azino-bis (3-ethylbenz-thiazoline-6-sulfonic acid) (ABTS) tests to assess the antioxidant properties of herbal and granule extract The results revealed that salvianolic acid B, sodium danshensu, and cryptotanshinone levels were much greater in the herbal extracts group than in the granule group. The increased ABTS, DPPH, and FRAP activities of the herbal extracts were correlated with this (P <.05). Salvianolic acid B concentration was the primary differentiator between granule extracts and other herbal extracts in the AHC and PCA analyses. In order to better educate healthcare practitioners and customers about the quality and effectiveness of granule products, the findings reinforce the necessity for their evaluation.

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